#Sketchy micro antibiotics skin#

п‚· Dark brown urine п‚· Facial swelling and edema п‚· Two weeks after onset of strep infection п‚· Early treatment will NOT prevent Treat-penicillin Virulence п‚§ Steptolysin O- lyse red blood cells п‚· Body makes antibodies against (ASO) п‚§ Streptokinase-plasmogenin to plasmin-can lyse clots п‚§ DNases-depolymerizes DNA Bacitracin sensitive Antistreptolysin O titer-done for diagnosis

#Sketchy micro antibiotics skin#

п‚§ Novobiocin sensitive o Saprophyticus п‚§ Novobiocin resistant п‚§ UTI-sexually active females п‚· пЂ пЂ пЂ Pie GeniesвЂ™ Bakery: Streptococcus pyrogenes o Gram positive long chains or pairs o Beta hemolytic o Encapsulated п‚§ Hyaluronic acid-in our tissue as well-not immunogenic o Impetigo-honey crusted skin o Pharyngitis o Cellulitis and erysipelas o Toxin diseases-strep pyrogenic exotoxin-SPE п‚§ Scarlet fever-reddening and swelling of tongue (strawberry tongue) pharyngitis Widespread rash that spares the face(Spe A and C) п‚§ Toxic shock like syndrome-TSLS-mediated by a superantigen (Spe A and C) п‚§ Necrotizing fasciitis-surgical treatment (SpeB) o Complications of Strep п‚§ Rheumatic fever п‚· ONLY AFTER PHAR п‚· Type II hypersensitivity п‚· M protein-highly antigenic and virulence factor interferes with opsinization (anti-phagocytic) and strong humoral response (molecular mimicry to myosin) п‚· Mitral valve-most commonly damaged-stenosis п‚· JONES o Joints-polyarthritis o Heart problems-myo and para carditis and murmurs o Subcutaneous nodules o Erythema marginatum-rash with thick red boarders o SydenhamвЂ™s chorea-rapid movements face and hands п‚· Early treatment will prevent п‚§ PSGN п‚· AFTER PHAR OR CUTANEOUS п‚· Type III hypersensitivity (post step stipper) п‚· Glomerular damage Notes: п‚· пЂ пЂ пЂ Golden Staff of Moses: Staph aureus o Gram positive cocci o Catalase positive o Coagulase positive o Beta hemolytic- Gold on blood agar o Look like a bundle of grapes o Plate on mannitol salt agar-turn agar yellow because it can ferment mannitol o Protein A-part of cell wall can bind Fc portion of antibodiesprevents compliment, opsinization, and phagocytosis o Colonizes nasopharynx o Symptoms п‚§ Pneumonia-patchy infiltrates on x ray п‚§ Usually a post viral infection pneumonia п‚§ Septic arthritis п‚§ Abscesses-impetigo, cellulitis, etc п‚§ Rapid onset-Endocarditis п‚· Worry IV drug user-usually right side tricuspid valve п‚§ Osteomyelitis-most common cause o Toxin mediated disease п‚§ Scalded skin syndrome-skin peals off due to exfoliation toxin п‚§ Toxic Shock Syndrome-TSST-superantigen-cytokine storm and shock п‚§ Staph food poisoning-rapid onset from preformed toxins-vomiting-meats and cream based foods o MRSA-alters PBPs п‚§ Treatment-Vancomycin or naficillin (Naf for staph) п‚· пЂ пЂ пЂ Beauty and the Plumber: Staph epidermidis and Staph saprophyticus o Gram positive o Catalase positive o Urease positive o Coagulase negative o Epidermidis п‚§ Infects prostetics, indwelling catheters, endocarditis in artificial heart valves (super important) п‚§ Biofilms-makes a lot of polysaccharides-resistant to many antibiotics п‚§ Treatment-Vancomycin surgical treatment of prosthetics may be needed п‚§ Part of normal skin flora contaminates blood cultures